SEMAPHORIN 3A - A NEW INTRATHYMIC SUPPRESSOR FACTOR
نویسندگان
چکیده
منابع مشابه
Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor.
Semaphorin 3A (Sema3A), a known inhibitor of axonal sprouting, also alters vascular patterning. Here we show that Sema3A selectively interferes with VEGF- but not bFGF-induced angiogenesis in vivo. Consistent with this, Sema3A disrupted VEGF- but not bFGF-mediated endothelial cell signaling to FAK and Src, key mediators of integrin and growth factor signaling; however, signaling to ERK by eithe...
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BACKGROUND Semaphorin 3A is a secreted protein that regulates cell motility and attachment in axon guidance, vascular growth, immune cell regulation and tumor progression. However, nothing is known about its role in kidney pathophysiology. Here, we determined whether semaphorin3A is induced after acute kidney injury (AKI) and whether urinary semaphorin 3A can predict AKI in humans undergoing ca...
متن کاملSemaphorin 3A, a potential immune regulator in Familial Mediterranean Fever
OBJECTIVES Semaphorin 3A (sema3A) plays a regulatory role in immune responses with effects on both T and B regulatory cells. Familial Mediterranean fever (FMF) is an autoinflammatory disease, yet a possible role for regulatory T and B cells has been described. METHODS 17 FMF patients during attack and then in remission, 8 FMF patients with smoldering disease and 12 healthy controls were enrol...
متن کاملSemaphorin 3A: A Potential Target for Low Back Pain
Low back pain is a common disorder. Pathological innervation and intervertebral disc degeneration are two major factors associated with this disease. Semaphorin 3A, originally known for its potent inhibiting effect on axonal outgrowth, is recently found to correlate with disease activity and histological features in some skeletal disorders. Based on its effects on innervation and vascularizatio...
متن کاملSemaphorin 3A blocks the formation of pathologic choroidal neovascularization induced by transforming growth factor beta
OBJECTIVE Choroidal neovascularization (CNV) is a major cause of vision loss in retinal diseases such as age-related macular degeneration (AMD). Previously, we demonstrated that semaphorin3A (Sema3A), which is a chemorepellent guidance molecule, inhibited the formation of retina neovascularization. In the present study, we investigated the antiangiogenic effects of Sema3A on transforming growth...
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ژورنال
عنوان ژورنال: Medical academic journal
سال: 2019
ISSN: 1608-4101
DOI: 10.17816/maj191s1203-205